AXL Mediates Resistance to Cetuximab Therapy
نویسندگان
چکیده
منابع مشابه
AXL mediates resistance to cetuximab therapy.
The EGFR antibody cetuximab is used to treat numerous cancers, but intrinsic and acquired resistance to this agent is a common clinical outcome. In this study, we show that overexpression of the oncogenic receptor tyrosine kinase AXL is sufficient to mediate acquired resistance to cetuximab in models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC), where ...
متن کاملMechanism of resistance to cetuximab therapy in colorectal cancer
The response rate to cetuximab, a chimeric (mouse-human) monoclonal antibody directed against epidermal growth factor receptor (EGFR), in colorectal cancer is low (10–15%), with significant inter-individual variability. Mechanisms proposed thus far to explain resistance to this therapy—such as the emergence of EGFR and KRAS mutations and aberrant ERBB2 signaling—do not account for the total int...
متن کاملYAP-Dependent AXL Overexpression Mediates Resistance to EGFR Inhibitors in NSCLC
The Yes-associated protein (YAP) is a transcriptional co-activator upregulating genes that promote cell growth and inhibit apoptosis. The main dysregulation of the Hippo pathway in tumors is due to YAP overexpression, promoting epithelial to mesenchymal transition, cell transformation, and increased metastatic ability. Moreover, it has recently been shown that YAP plays a role in sustaining res...
متن کاملEpidermal growth factor receptor mutation mediates cross-resistance to panitumumab and cetuximab in gastrointestinal cancer
Acquired resistance to epidermal growth factor receptor (EGFR) targeted antibodies represents a clinical challenge in the treatment of gastrointestinal tumors such as metastatic colorectal cancer, but its molecular mechanisms are incompletely understood. We scanned KRAS exon 2/3/4, NRAS exon 2/3/4 and the overlapping epitopes of the EGFR antibodies cetuximab and panitumumab for mutations in pre...
متن کاملResistance to HER2-targeted therapy
Production and approval of trastuzumab (Herceptin®) for the treatment of metastatic breast cancer (MBC) was a millstone in antibody-based targeted therapy in the cancer treatment. However, despite the early success in the clinical trials, trastuzumab failed to appreciate the initial attraction due to development of resistance to the drug. The majority of patients who benefit from the drug...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2014
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-14-0294